diff --git a/lib/pleroma/user.ex b/lib/pleroma/user.ex
index f7191762f..ed5403219 100644
--- a/lib/pleroma/user.ex
+++ b/lib/pleroma/user.ex
@@ -836,15 +836,15 @@ def unblock(blocker, %{ap_id: ap_id}) do
   def mutes?(nil, _), do: false
   def mutes?(user, %{ap_id: ap_id}), do: Enum.member?(user.info.mutes, ap_id)
 
-  def blocks?(user, %{ap_id: ap_id}) do
-    blocks = user.info.blocks
-    domain_blocks = user.info.domain_blocks
+  def blocks?(%User{info: info} = _user, %{ap_id: ap_id}) do
+    blocks = info.blocks
+
+    domain_blocks = Pleroma.Web.ActivityPub.MRF.subdomains_regex(info.domain_blocks)
+
     %{host: host} = URI.parse(ap_id)
 
     Enum.member?(blocks, ap_id) ||
-      Enum.any?(domain_blocks, fn domain ->
-        host == domain
-      end)
+      Pleroma.Web.ActivityPub.MRF.subdomain_match?(domain_blocks, host)
   end
 
   def subscribed_to?(user, %{ap_id: ap_id}) do
diff --git a/lib/pleroma/web/activity_pub/mrf.ex b/lib/pleroma/web/activity_pub/mrf.ex
index 10ceef715..dd204b21c 100644
--- a/lib/pleroma/web/activity_pub/mrf.ex
+++ b/lib/pleroma/web/activity_pub/mrf.ex
@@ -25,4 +25,14 @@ def get_policies do
   defp get_policies(policy) when is_atom(policy), do: [policy]
   defp get_policies(policies) when is_list(policies), do: policies
   defp get_policies(_), do: []
+
+  @spec subdomains_regex([String.t()]) :: [Regex.t()]
+  def subdomains_regex(domains) when is_list(domains) do
+    for domain <- domains, do: ~r(^#{String.replace(domain, "*.", "(.*\\.)*")}$)
+  end
+
+  @spec subdomain_match?([Regex.t()], String.t()) :: boolean()
+  def subdomain_match?(domains, host) do
+    Enum.any?(domains, fn domain -> Regex.match?(domain, host) end)
+  end
 end
diff --git a/lib/pleroma/web/activity_pub/mrf/simple_policy.ex b/lib/pleroma/web/activity_pub/mrf/simple_policy.ex
index 433d23c5f..2cf63d3db 100644
--- a/lib/pleroma/web/activity_pub/mrf/simple_policy.ex
+++ b/lib/pleroma/web/activity_pub/mrf/simple_policy.ex
@@ -4,22 +4,29 @@
 
 defmodule Pleroma.Web.ActivityPub.MRF.SimplePolicy do
   alias Pleroma.User
+  alias Pleroma.Web.ActivityPub.MRF
   @moduledoc "Filter activities depending on their origin instance"
-  @behaviour Pleroma.Web.ActivityPub.MRF
+  @behaviour MRF
 
   defp check_accept(%{host: actor_host} = _actor_info, object) do
-    accepts = Pleroma.Config.get([:mrf_simple, :accept])
+    accepts =
+      Pleroma.Config.get([:mrf_simple, :accept])
+      |> MRF.subdomains_regex()
 
     cond do
       accepts == [] -> {:ok, object}
       actor_host == Pleroma.Config.get([Pleroma.Web.Endpoint, :url, :host]) -> {:ok, object}
-      Enum.member?(accepts, actor_host) -> {:ok, object}
+      MRF.subdomain_match?(accepts, actor_host) -> {:ok, object}
       true -> {:reject, nil}
     end
   end
 
   defp check_reject(%{host: actor_host} = _actor_info, object) do
-    if Enum.member?(Pleroma.Config.get([:mrf_simple, :reject]), actor_host) do
+    rejects =
+      Pleroma.Config.get([:mrf_simple, :reject])
+      |> MRF.subdomains_regex()
+
+    if MRF.subdomain_match?(rejects, actor_host) do
       {:reject, nil}
     else
       {:ok, object}
@@ -31,8 +38,12 @@ defp check_media_removal(
          %{"type" => "Create", "object" => %{"attachment" => child_attachment}} = object
        )
        when length(child_attachment) > 0 do
+    media_removal =
+      Pleroma.Config.get([:mrf_simple, :media_removal])
+      |> MRF.subdomains_regex()
+
     object =
-      if Enum.member?(Pleroma.Config.get([:mrf_simple, :media_removal]), actor_host) do
+      if MRF.subdomain_match?(media_removal, actor_host) do
         child_object = Map.delete(object["object"], "attachment")
         Map.put(object, "object", child_object)
       else
@@ -51,8 +62,12 @@ defp check_media_nsfw(
            "object" => child_object
          } = object
        ) do
+    media_nsfw =
+      Pleroma.Config.get([:mrf_simple, :media_nsfw])
+      |> MRF.subdomains_regex()
+
     object =
-      if Enum.member?(Pleroma.Config.get([:mrf_simple, :media_nsfw]), actor_host) do
+      if MRF.subdomain_match?(media_nsfw, actor_host) do
         tags = (child_object["tag"] || []) ++ ["nsfw"]
         child_object = Map.put(child_object, "tag", tags)
         child_object = Map.put(child_object, "sensitive", true)
@@ -67,12 +82,12 @@ defp check_media_nsfw(
   defp check_media_nsfw(_actor_info, object), do: {:ok, object}
 
   defp check_ftl_removal(%{host: actor_host} = _actor_info, object) do
+    timeline_removal =
+      Pleroma.Config.get([:mrf_simple, :federated_timeline_removal])
+      |> MRF.subdomains_regex()
+
     object =
-      with true <-
-             Enum.member?(
-               Pleroma.Config.get([:mrf_simple, :federated_timeline_removal]),
-               actor_host
-             ),
+      with true <- MRF.subdomain_match?(timeline_removal, actor_host),
            user <- User.get_cached_by_ap_id(object["actor"]),
            true <- "https://www.w3.org/ns/activitystreams#Public" in object["to"] do
         to =
@@ -94,7 +109,11 @@ defp check_ftl_removal(%{host: actor_host} = _actor_info, object) do
   end
 
   defp check_report_removal(%{host: actor_host} = _actor_info, %{"type" => "Flag"} = object) do
-    if actor_host in Pleroma.Config.get([:mrf_simple, :report_removal]) do
+    report_removal =
+      Pleroma.Config.get([:mrf_simple, :report_removal])
+      |> MRF.subdomains_regex()
+
+    if MRF.subdomain_match?(report_removal, actor_host) do
       {:reject, nil}
     else
       {:ok, object}
@@ -104,7 +123,11 @@ defp check_report_removal(%{host: actor_host} = _actor_info, %{"type" => "Flag"}
   defp check_report_removal(_actor_info, object), do: {:ok, object}
 
   defp check_avatar_removal(%{host: actor_host} = _actor_info, %{"icon" => _icon} = object) do
-    if actor_host in Pleroma.Config.get([:mrf_simple, :avatar_removal]) do
+    avatar_removal =
+      Pleroma.Config.get([:mrf_simple, :avatar_removal])
+      |> MRF.subdomains_regex()
+
+    if MRF.subdomain_match?(avatar_removal, actor_host) do
       {:ok, Map.delete(object, "icon")}
     else
       {:ok, object}
@@ -114,7 +137,11 @@ defp check_avatar_removal(%{host: actor_host} = _actor_info, %{"icon" => _icon}
   defp check_avatar_removal(_actor_info, object), do: {:ok, object}
 
   defp check_banner_removal(%{host: actor_host} = _actor_info, %{"image" => _image} = object) do
-    if actor_host in Pleroma.Config.get([:mrf_simple, :banner_removal]) do
+    banner_removal =
+      Pleroma.Config.get([:mrf_simple, :banner_removal])
+      |> MRF.subdomains_regex()
+
+    if MRF.subdomain_match?(banner_removal, actor_host) do
       {:ok, Map.delete(object, "image")}
     else
       {:ok, object}
diff --git a/lib/pleroma/web/activity_pub/publisher.ex b/lib/pleroma/web/activity_pub/publisher.ex
index a05e03263..3d181f57c 100644
--- a/lib/pleroma/web/activity_pub/publisher.ex
+++ b/lib/pleroma/web/activity_pub/publisher.ex
@@ -87,8 +87,13 @@ defp should_federate?(inbox, public) do
     if public do
       true
     else
-      inbox_info = URI.parse(inbox)
-      !Enum.member?(Config.get([:instance, :quarantined_instances], []), inbox_info.host)
+      %{host: host} = URI.parse(inbox)
+
+      quarantined_instances =
+        Config.get([:instance, :quarantined_instances], [])
+        |> Pleroma.Web.ActivityPub.MRF.subdomains_regex()
+
+      !Pleroma.Web.ActivityPub.MRF.subdomain_match?(quarantined_instances, host)
     end
   end
 
diff --git a/test/user_test.exs b/test/user_test.exs
index 198a97fae..7bd745104 100644
--- a/test/user_test.exs
+++ b/test/user_test.exs
@@ -799,6 +799,48 @@ test "blocks domains" do
       assert User.blocks?(user, collateral_user)
     end
 
+    test "does not block domain with same end" do
+      user = insert(:user)
+
+      collateral_user =
+        insert(:user, %{ap_id: "https://another-awful-and-rude-instance.com/user/bully"})
+
+      {:ok, user} = User.block_domain(user, "awful-and-rude-instance.com")
+
+      refute User.blocks?(user, collateral_user)
+    end
+
+    test "does not block domain with same end if wildcard added" do
+      user = insert(:user)
+
+      collateral_user =
+        insert(:user, %{ap_id: "https://another-awful-and-rude-instance.com/user/bully"})
+
+      {:ok, user} = User.block_domain(user, "*.awful-and-rude-instance.com")
+
+      refute User.blocks?(user, collateral_user)
+    end
+
+    test "blocks domain with wildcard for subdomain" do
+      user = insert(:user)
+
+      user_from_subdomain =
+        insert(:user, %{ap_id: "https://subdomain.awful-and-rude-instance.com/user/bully"})
+
+      user_with_two_subdomains =
+        insert(:user, %{
+          ap_id: "https://subdomain.second_subdomain.awful-and-rude-instance.com/user/bully"
+        })
+
+      user_domain = insert(:user, %{ap_id: "https://awful-and-rude-instance.com/user/bully"})
+
+      {:ok, user} = User.block_domain(user, "*.awful-and-rude-instance.com")
+
+      assert User.blocks?(user, user_from_subdomain)
+      assert User.blocks?(user, user_with_two_subdomains)
+      assert User.blocks?(user, user_domain)
+    end
+
     test "unblocks domains" do
       user = insert(:user)
       collateral_user = insert(:user, %{ap_id: "https://awful-and-rude-instance.com/user/bully"})
diff --git a/test/web/activity_pub/mrf/mrf_test.exs b/test/web/activity_pub/mrf/mrf_test.exs
new file mode 100644
index 000000000..a9cdf5317
--- /dev/null
+++ b/test/web/activity_pub/mrf/mrf_test.exs
@@ -0,0 +1,46 @@
+defmodule Pleroma.Web.ActivityPub.MRFTest do
+  use ExUnit.Case, async: true
+  alias Pleroma.Web.ActivityPub.MRF
+
+  test "subdomains_regex/1" do
+    assert MRF.subdomains_regex(["unsafe.tld", "*.unsafe.tld"]) == [
+             ~r/^unsafe.tld$/,
+             ~r/^(.*\.)*unsafe.tld$/
+           ]
+  end
+
+  describe "subdomain_match/2" do
+    test "common domains" do
+      regexes = MRF.subdomains_regex(["unsafe.tld", "unsafe2.tld"])
+
+      assert regexes == [~r/^unsafe.tld$/, ~r/^unsafe2.tld$/]
+
+      assert MRF.subdomain_match?(regexes, "unsafe.tld")
+      assert MRF.subdomain_match?(regexes, "unsafe2.tld")
+
+      refute MRF.subdomain_match?(regexes, "example.com")
+    end
+
+    test "wildcard domains with one subdomain" do
+      regexes = MRF.subdomains_regex(["*.unsafe.tld"])
+
+      assert regexes == [~r/^(.*\.)*unsafe.tld$/]
+
+      assert MRF.subdomain_match?(regexes, "unsafe.tld")
+      assert MRF.subdomain_match?(regexes, "sub.unsafe.tld")
+      refute MRF.subdomain_match?(regexes, "anotherunsafe.tld")
+      refute MRF.subdomain_match?(regexes, "unsafe.tldanother")
+    end
+
+    test "wildcard domains with two subdomains" do
+      regexes = MRF.subdomains_regex(["*.unsafe.tld"])
+
+      assert regexes == [~r/^(.*\.)*unsafe.tld$/]
+
+      assert MRF.subdomain_match?(regexes, "unsafe.tld")
+      assert MRF.subdomain_match?(regexes, "sub.sub.unsafe.tld")
+      refute MRF.subdomain_match?(regexes, "sub.anotherunsafe.tld")
+      refute MRF.subdomain_match?(regexes, "sub.unsafe.tldanother")
+    end
+  end
+end
diff --git a/test/web/activity_pub/mrf/simple_policy_test.exs b/test/web/activity_pub/mrf/simple_policy_test.exs
index 0fd68e103..8e86d2219 100644
--- a/test/web/activity_pub/mrf/simple_policy_test.exs
+++ b/test/web/activity_pub/mrf/simple_policy_test.exs
@@ -49,6 +49,19 @@ test "has a matching host" do
 
       assert SimplePolicy.filter(local_message) == {:ok, local_message}
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :media_removal], ["*.remote.instance"])
+      media_message = build_media_message()
+      local_message = build_local_message()
+
+      assert SimplePolicy.filter(media_message) ==
+               {:ok,
+                media_message
+                |> Map.put("object", Map.delete(media_message["object"], "attachment"))}
+
+      assert SimplePolicy.filter(local_message) == {:ok, local_message}
+    end
   end
 
   describe "when :media_nsfw" do
@@ -74,6 +87,20 @@ test "has a matching host" do
 
       assert SimplePolicy.filter(local_message) == {:ok, local_message}
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :media_nsfw], ["*.remote.instance"])
+      media_message = build_media_message()
+      local_message = build_local_message()
+
+      assert SimplePolicy.filter(media_message) ==
+               {:ok,
+                media_message
+                |> put_in(["object", "tag"], ["foo", "nsfw"])
+                |> put_in(["object", "sensitive"], true)}
+
+      assert SimplePolicy.filter(local_message) == {:ok, local_message}
+    end
   end
 
   defp build_media_message do
@@ -106,6 +133,15 @@ test "has a matching host" do
       assert SimplePolicy.filter(report_message) == {:reject, nil}
       assert SimplePolicy.filter(local_message) == {:ok, local_message}
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :report_removal], ["*.remote.instance"])
+      report_message = build_report_message()
+      local_message = build_local_message()
+
+      assert SimplePolicy.filter(report_message) == {:reject, nil}
+      assert SimplePolicy.filter(local_message) == {:ok, local_message}
+    end
   end
 
   defp build_report_message do
@@ -146,6 +182,27 @@ test "has a matching host" do
       assert SimplePolicy.filter(local_message) == {:ok, local_message}
     end
 
+    test "match with wildcard domain" do
+      {actor, ftl_message} = build_ftl_actor_and_message()
+
+      ftl_message_actor_host =
+        ftl_message
+        |> Map.fetch!("actor")
+        |> URI.parse()
+        |> Map.fetch!(:host)
+
+      Config.put([:mrf_simple, :federated_timeline_removal], ["*." <> ftl_message_actor_host])
+      local_message = build_local_message()
+
+      assert {:ok, ftl_message} = SimplePolicy.filter(ftl_message)
+      assert actor.follower_address in ftl_message["to"]
+      refute actor.follower_address in ftl_message["cc"]
+      refute "https://www.w3.org/ns/activitystreams#Public" in ftl_message["to"]
+      assert "https://www.w3.org/ns/activitystreams#Public" in ftl_message["cc"]
+
+      assert SimplePolicy.filter(local_message) == {:ok, local_message}
+    end
+
     test "has a matching host but only as:Public in to" do
       {_actor, ftl_message} = build_ftl_actor_and_message()
 
@@ -192,6 +249,14 @@ test "has a matching host" do
 
       assert SimplePolicy.filter(remote_message) == {:reject, nil}
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :reject], ["*.remote.instance"])
+
+      remote_message = build_remote_message()
+
+      assert SimplePolicy.filter(remote_message) == {:reject, nil}
+    end
   end
 
   describe "when :accept" do
@@ -224,6 +289,16 @@ test "has a matching host" do
       assert SimplePolicy.filter(local_message) == {:ok, local_message}
       assert SimplePolicy.filter(remote_message) == {:ok, remote_message}
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :accept], ["*.remote.instance"])
+
+      local_message = build_local_message()
+      remote_message = build_remote_message()
+
+      assert SimplePolicy.filter(local_message) == {:ok, local_message}
+      assert SimplePolicy.filter(remote_message) == {:ok, remote_message}
+    end
   end
 
   describe "when :avatar_removal" do
@@ -251,6 +326,15 @@ test "has a matching host" do
 
       refute filtered["icon"]
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :avatar_removal], ["*.remote.instance"])
+
+      remote_user = build_remote_user()
+      {:ok, filtered} = SimplePolicy.filter(remote_user)
+
+      refute filtered["icon"]
+    end
   end
 
   describe "when :banner_removal" do
@@ -278,6 +362,15 @@ test "has a matching host" do
 
       refute filtered["image"]
     end
+
+    test "match with wildcard domain" do
+      Config.put([:mrf_simple, :banner_removal], ["*.remote.instance"])
+
+      remote_user = build_remote_user()
+      {:ok, filtered} = SimplePolicy.filter(remote_user)
+
+      refute filtered["image"]
+    end
   end
 
   defp build_local_message do