diff --git a/config/config.exs b/config/config.exs
index d31208c25..ba263bf95 100644
--- a/config/config.exs
+++ b/config/config.exs
@@ -509,7 +509,8 @@ config :pleroma, Pleroma.User,
     "user_exists",
     "users",
     "web"
-  ]
+  ],
+  email_blacklist: []
 
 config :pleroma, Oban,
   repo: Pleroma.Repo,
diff --git a/config/description.exs b/config/description.exs
index 11fbe0d78..3fe22e969 100644
--- a/config/description.exs
+++ b/config/description.exs
@@ -3021,6 +3021,7 @@ config :pleroma, :config_description, [
       %{
         key: :restricted_nicknames,
         type: {:list, :string},
+        description: "List of nicknames users may not register with.",
         suggestions: [
           ".well-known",
           "~",
@@ -3053,6 +3054,12 @@ config :pleroma, :config_description, [
           "users",
           "web"
         ]
+      },
+      %{
+        key: :email_blacklist,
+        type: {:list, :string},
+        description: "List of email domains users may not register with.",
+        suggestions: ["mailinator.com", "maildrop.cc"]
       }
     ]
   },
diff --git a/docs/configuration/cheatsheet.md b/docs/configuration/cheatsheet.md
index 9c768abef..1a86179f3 100644
--- a/docs/configuration/cheatsheet.md
+++ b/docs/configuration/cheatsheet.md
@@ -202,6 +202,11 @@ config :pleroma, :mrf_user_allowlist, %{
 * `sign_object_fetches`: Sign object fetches with HTTP signatures
 * `authorized_fetch_mode`: Require HTTP signatures for AP fetches
 
+## Pleroma.User
+
+* `restricted_nicknames`: List of nicknames users may not register with.
+* `email_blacklist`: List of email domains users may not register with.
+
 ## Pleroma.ScheduledActivity
 
 * `daily_user_limit`: the number of scheduled activities a user is allowed to create in a single day (Default: `25`)
diff --git a/lib/pleroma/user.ex b/lib/pleroma/user.ex
index dcf6ebee2..d0cc098fe 100644
--- a/lib/pleroma/user.ex
+++ b/lib/pleroma/user.ex
@@ -676,10 +676,19 @@ defmodule Pleroma.User do
     |> validate_required([:name, :nickname, :password, :password_confirmation])
     |> validate_confirmation(:password)
     |> unique_constraint(:email)
+    |> validate_format(:email, @email_regex)
+    |> validate_change(:email, fn :email, email ->
+      valid? =
+        Config.get([User, :email_blacklist])
+        |> Enum.all?(fn blacklisted_domain ->
+          !String.ends_with?(email, ["@" <> blacklisted_domain, "." <> blacklisted_domain])
+        end)
+
+      if valid?, do: [], else: [email: "Email domain is blacklisted"]
+    end)
     |> unique_constraint(:nickname)
     |> validate_exclusion(:nickname, Config.get([User, :restricted_nicknames]))
     |> validate_format(:nickname, local_nickname_regex())
-    |> validate_format(:email, @email_regex)
     |> validate_length(:bio, max: bio_limit)
     |> validate_length(:name, min: 1, max: name_limit)
     |> validate_length(:registration_reason, max: reason_limit)
diff --git a/test/user_test.exs b/test/user_test.exs
index 904cea536..7c45e69e7 100644
--- a/test/user_test.exs
+++ b/test/user_test.exs
@@ -490,6 +490,29 @@ defmodule Pleroma.UserTest do
       refute changeset.valid?
     end
 
+    test "it blocks blacklisted email domains" do
+      clear_config([User, :email_blacklist], ["trolling.world"])
+
+      # Block with match
+      params = Map.put(@full_user_data, :email, "troll@trolling.world")
+      changeset = User.register_changeset(%User{}, params)
+      refute changeset.valid?
+
+      # Block with subdomain match
+      params = Map.put(@full_user_data, :email, "troll@gnomes.trolling.world")
+      changeset = User.register_changeset(%User{}, params)
+      refute changeset.valid?
+
+      # Pass with different domains that are similar
+      params = Map.put(@full_user_data, :email, "troll@gnomestrolling.world")
+      changeset = User.register_changeset(%User{}, params)
+      assert changeset.valid?
+
+      params = Map.put(@full_user_data, :email, "troll@trolling.world.us")
+      changeset = User.register_changeset(%User{}, params)
+      assert changeset.valid?
+    end
+
     test "it sets the password_hash and ap_id" do
       changeset = User.register_changeset(%User{}, @full_user_data)