diff --git a/lib/pleroma/web/activity_pub/utils.ex b/lib/pleroma/web/activity_pub/utils.ex
index b15be8b22..008aec475 100644
--- a/lib/pleroma/web/activity_pub/utils.ex
+++ b/lib/pleroma/web/activity_pub/utils.ex
@@ -507,19 +507,37 @@ def fetch_latest_undo(%User{ap_id: ap_id}) do
 
   def get_latest_reaction(internal_activity_id, %{ap_id: ap_id}, emoji) do
     %{data: %{"object" => object_ap_id}} = Activity.get_by_id(internal_activity_id)
-
     emoji = Pleroma.Emoji.maybe_quote(emoji)
 
     "EmojiReact"
     |> Activity.Queries.by_type()
     |> where(actor: ^ap_id)
-    |> where([activity], fragment("?->>'content' = ?", activity.data, ^emoji))
+    |> custom_emoji_discriminator(emoji)
     |> Activity.Queries.by_object_id(object_ap_id)
     |> order_by([activity], fragment("? desc nulls last", activity.id))
     |> limit(1)
     |> Repo.one()
   end
 
+  defp custom_emoji_discriminator(query, emoji) do
+    if String.contains?(emoji, "@") do
+      stripped = Pleroma.Emoji.stripped_name(emoji)
+      [name, domain] = String.split(stripped, "@")
+      domain_pattern = "%" <> domain <> "%"
+      emoji_pattern = Pleroma.Emoji.maybe_quote(name)
+
+      query
+      |> where([activity], fragment("?->>'content' = ?
+        AND EXISTS (
+          SELECT FROM jsonb_array_elements(?->'tag') elem
+          WHERE elem->>'id' ILIKE ?
+        )", activity.data, ^emoji_pattern, activity.data, ^domain_pattern))
+    else
+      query
+      |> where([activity], fragment("?->>'content' = ?", activity.data, ^emoji))
+    end
+  end
+
   #### Announce-related helpers
 
   @doc """
diff --git a/test/pleroma/web/pleroma_api/controllers/emoji_reaction_controller_test.exs b/test/pleroma/web/pleroma_api/controllers/emoji_reaction_controller_test.exs
index 9fb683262..6864b37cb 100644
--- a/test/pleroma/web/pleroma_api/controllers/emoji_reaction_controller_test.exs
+++ b/test/pleroma/web/pleroma_api/controllers/emoji_reaction_controller_test.exs
@@ -98,6 +98,20 @@ test "PUT /api/v1/pleroma/statuses/:id/reactions/:emoji", %{conn: conn} do
              }
            ]
 
+    # Reacting with a remote custom emoji that hasn't been reacted with yet
+    note =
+      insert(:note,
+        user: user
+      )
+
+    activity = insert(:note_activity, note: note, user: user)
+
+    assert conn
+           |> assign(:user, user)
+           |> assign(:token, insert(:oauth_token, user: user, scopes: ["write:statuses"]))
+           |> put("/api/v1/pleroma/statuses/#{activity.id}/reactions/:wow@remote:")
+           |> json_response(400)
+
     # Reacting with a non-emoji
     assert conn
            |> assign(:user, other_user)
@@ -110,10 +124,22 @@ test "DELETE /api/v1/pleroma/statuses/:id/reactions/:emoji", %{conn: conn} do
     user = insert(:user)
     other_user = insert(:user)
 
-    {:ok, activity} = CommonAPI.post(user, %{status: "#cofe"})
+    note =
+      insert(:note,
+        user: user,
+        data: %{"reactions" => [["wow", [user.ap_id], "https://remote/emoji/wow"]]}
+      )
+
+    activity = insert(:note_activity, note: note, user: user)
+
+    ObanHelpers.perform_all()
+
     {:ok, _reaction_activity} = CommonAPI.react_with_emoji(activity.id, other_user, "☕")
     {:ok, _reaction_activity} = CommonAPI.react_with_emoji(activity.id, other_user, ":dinosaur:")
 
+    {:ok, _reaction_activity} =
+      CommonAPI.react_with_emoji(activity.id, other_user, ":wow@remote:")
+
     ObanHelpers.perform_all()
 
     result =
@@ -140,7 +166,32 @@ test "DELETE /api/v1/pleroma/statuses/:id/reactions/:emoji", %{conn: conn} do
 
     object = Object.get_by_ap_id(activity.data["object"])
 
-    assert object.data["reaction_count"] == 0
+    assert object.data["reaction_count"] == 2
+
+    # Remove custom remote emoji
+    result =
+      conn
+      |> assign(:user, other_user)
+      |> assign(:token, insert(:oauth_token, user: other_user, scopes: ["write:statuses"]))
+      |> delete("/api/v1/pleroma/statuses/#{activity.id}/reactions/:wow@remote:")
+      |> json_response(200)
+
+    assert result["pleroma"]["emoji_reactions"] == [
+             %{
+               "name" => "wow@remote",
+               "count" => 1,
+               "me" => false,
+               "url" => "https://remote/emoji/wow",
+               "account_ids" => [user.id]
+             }
+           ]
+
+    # Remove custom remote emoji that hasn't been reacted with yet
+    assert conn
+           |> assign(:user, other_user)
+           |> assign(:token, insert(:oauth_token, user: other_user, scopes: ["write:statuses"]))
+           |> delete("/api/v1/pleroma/statuses/#{activity.id}/reactions/:zoop@remote:")
+           |> json_response(400)
   end
 
   test "GET /api/v1/pleroma/statuses/:id/reactions", %{conn: conn} do